<a href="https://coingenius.news/wp-content/uploads/2024/03/molecular-imaging-technique-could-improve-breast-cancer-screening-physics-world-3.jpg" data-fancybox data-src="https://coingenius.news/wp-content/uploads/2024/03/molecular-imaging-technique-could-improve-breast-cancer-screening-physics-world-3.jpg" data-caption="Ukutholwa komdlavuza Izithombe ze-mammographic (A, B) zezilonda ebeleni lesokunxele, ziqinisekiswa njenge-invasive ductal carcinoma (umcibisholo) kanye ne-fibroadenoma (umcibisholo okabili). Izithombe ze-PEM ezingakwesokunxele (C, D) zibonisa ukuthambekela okukhulu kumdlavuza owaziwayo futhi akukho ukuthatha ku-fibroadenoma. Izithombe ze-PEM ezingakwesokudla (E, F) azibonisi ukuthatha okungavamile. Izithombe ze-PEM ezingakwesokunxele zithole ihora elingu-1 (G) namahora angu-4 (H) ngemva kwalokho ¹⁸Umjovo we-F-FDG awubonisi umehluko omkhulu wokubonwayo ekuthatheni. (Ngomusa: I-Radiological Society of North America)”>

I-Mammography iyithuluzi elisetshenziswa kakhulu futhi elisebenzayo lokutholwa komdlavuza webele kusenesikhathi, kodwa amabele aminyene abeka inselele enkulu ekuhlolweni komdlavuza. Akukona nje kuphela ukuthi izicubu zebele eziminyene zandisa ingozi yokuba nomdlavuza webele, ingxenye enkulu yezicubu ezine-fibrous ne-glaular ingafihla ubukhona besimila ku-mammogram yokuhlola.

Ngenxa yalokhu, izindlela ezengeziwe ze-breast imaging zivame ukwelulekwa kwabesifazane abanamabele aminyene. Ukuhlola okunjalo, i-MRI yebele ikakhulukazi, kwengeza kakhulu izindleko zokuhlolwa komdlavuza. Lokhu kuyinkinga ikakhulukazi uma kucatshangelwa ukuthi cishe u-40% wabantu abahlolwayo banamabele aminyene ngendlela ehlukahlukene futhi cishe u-10% wabesifazane unamabele aminyene kakhulu.

Idosi ephansi ye-positron emission mammography (PEM) iyindlela entsha yokuthwebula ibele yamangqamuzana engase ithathe indawo noma yengezelele i-mammography. Benalokhu engqondweni, abacwaningi baseCanada baye baqhathanisa ukusebenza kwe-PEM ne-MRI yebele ekuhlonzeni umdlavuza webele nasekutholeni izinga lawo lendawo kwabesifazane abangu-25 abasanda kutholakala benomdlavuza wamabele. Babika imiphumela yocwaningo lwabo lomtholampilo ku I-Radiology: I-Maging Cancer.

<a data-fancybox data-src="https://coingenius.news/wp-content/uploads/2024/03/molecular-imaging-technique-could-improve-breast-cancer-screening-physics-world-1.jpg" data-caption="Isithombe se-Radialis PET Uhlelo lwe-PET oluqondiswe esithweni luletha umthamo wemisebe ofana nowe-mammography ngaphandle kwesidingo sokucindezelwa kwebele. (Izilokotho: I-Radiological Society of North America)” title=”Chofoza ukuze uvule isithombe ku-popup” href=”https://coingenius.news/wp-content/uploads/2024/03/molecular-imaging-technique-could-improve -i-breast-cancer-screening-physics-world-1.jpg”>

Ngokomlando, izithombe zebele zamangqamuzana azizange zisetshenziselwe ukuthwebula izithombe zebele ngenxa yomthamo ophezulu wemisebe eliwulethayo emabeleni nasezithweni ezizungezile. Ukusetshenziswa kwesistimu ye-PET eqondiswe kumzimba - the Isithombe se-Radialis PET - ukwenza i-PEM kungaqeda lokhu kukhathazeka. I-Radialis isebenzisa ukutholwa kwezinto ngengozi kwama-gamma photon, eqeda isidingo sokungqubuzana (okudingekayo ukuze kutholwe isithombe sesifuba semolekyuli yekhamera ye-gamma) futhi ivumele ukusetshenziswa kwemithamo yemisebe eqhathaniswa naleyo ye-mammography.

Ubuchwepheshe be-PEM bunikeza ukuzwela okuphezulu kwe-MRI yebele kodwa ngenzuzo yokuba ngaphansi kwezindleko. Umthamo wayo wemisebe osebenzayo uqhathaniswa nowendabuko wedijithali we-mammography futhi uphansi kune-tomosynthesis yedijithali. Ngaphezu kwalokho, i-PEM inqoba izinkinga zokufihla isimila ezihambisana nokuminyana okuphezulu kwamabele, iletha amanga ambalwa kune-mammography, futhi ayidingi ukucindezelwa kwebele ngesikhathi sokuhlolwa.

Umphenyi omkhulu UVivianne Freitas, ukusuka I-University of Toronto's University Health Network, ISinayi Health futhi Zabesifazane College Hospital, nozakwethu bafanekisela ababambiqhaza bocwaningo ihora elingu-1 nehora lesi-4 ngemva kokujova okungu-37, 74 noma 185 MBq kwe-radiotracer. ¹⁸I-F-fluorodeoxyglucose (¹⁸F-FDG). Ngokufana ne-mammography, bathole izithombe ze-PEM ekubukeni okujwayelekile kwe-craniocaudal kanye ne-mediolateral oblique.

Izazi ezimbili ze-radiologist zamabele eziphuphuthekiswe indawo yomdlavuza zenze ukuhlola okubonwa kwezilonda ngakunye kwezithombe ezitholiwe, ziqopha ukwakheka kwanoma yiziphi izilonda ezibonwayo. I-PEM yomthamo ophansi ikhombe izilonda eziyingozi ezaziwayo ezingama-24 kwezingu-25 (ezinqunywa i-histopathology) uma kuqhathaniswa no-100% we-MRI, yehluleka ukuthola umdlavuza owodwa we-38-mm lobular. I-MRI ihlonze izilonda ezengeziwe ezingu-13, eziyisishiyagalombili zazo ezazinamanga, kuyilapho i-PEM ithole eziyisithupha, enye yazo yayingamanga, ebonisa izinga eliphansi le-PEM lamanga le-16% uma liqhathaniswa ne-62% ye-MRI.

Abacwaningi baqaphela ukuthi umthamo ophansi we-PEM ongu-37–185 MBq ukhiqize izithombe zekhwalithi yokuxilonga ezihambisana nokuchayeka emisebeni engu-0.62–0.71 kuya ku-1.24–1.42 mSv. Umthamo ophansi wedivayisi ye-PEM usondele esilinganisweni esiphelele somthamo osebenzayo we-mammography yedijithali ebuka kabili-ububanzi obugcwele (cishe u-0.44 mSv), yayifana ne-mammography ethuthukisiwe (0.58 mSv) futhi ingaphansi kwenhlanganisela ye-mammography nesifuba sedijithali. i-tomosynthesis (0.88 mSv).

“Ukuze kuhlolwe, ikhono le-PEM lokwenza kahle kungakhathaliseki ukuthi ibele liminyene kangakanani lingase libhekane nokushoda okukhulu kwe-mammography, ikakhulukazi ekutholeni umdlavuza emabeleni aminyene lapho izilonda zingase zingabonakali khona,” kusho uFreitas. "Iphinde inikeze inketho esebenzayo ezigulini ezisengozini enkulu ezine-claustrophobic noma ezine-contraindications ye-MRI."

UFreitas uphawula ukuthi nakuba ukuhlanganiswa okuphelele kwe-PEM emisebenzini yomtholampilo kusazoqinisekiswa, lokhu okutholakele kokuqala kuyathembisa, ikakhulukazi njengoba kukhombisa amandla e-PEM okuthola umdlavuza webele ohlaselayo ¹⁸Imithamo ye-F-FDG. "Lokhu kuphawula isinyathelo sokuqala esibalulekile ekusetshenzisweni kwayo esikhathini esizayo ekusebenzeni komtholampilo," usho kanje.

Abacwaningi manje sebeqale a isifundo somshayeli ukuhlola ukuthi ukutholakala kwe-liquid biopsy kungafaniswa yini nezithombe ezitholwe yi-PEM kwabesifazane abasengozini enkulu yomdlavuza webele. Ababambiqhaza bathathwe igazi ukuze kuhlolwe i-liquid biopsy kanye nokuhlolwa kwe-PEM kulandela umjovo ongu-74 MBq we ¹⁸F-FDG, ngaphambi kokwenza i-biopsy eqondiswa yi-MRI yesilonda sebele esolisayo.

Ithimba lizohlola idatha evela ezivivinyweni ezimbili ukuze linqume ukuthi ingabe kukhona yini okutholwe inoveli ngosayizi wesiqephu sesimila namaphethini, amasiginesha ashintshashintshayo, okuhlukile noma izinguquko ze-epigenetic ezikhonjwe ku-biopsy ewuketshezi zihambisana nezici zezithombe ze-PEM. Uma kuhlonzwa ukuhlobana phakathi kwalokhu okubili, abacwaningi bahlela ukwenza izifundo ezengeziwe ukuze bahlole ukuthi lezi zindlela zingasiza yini ukucolisa uphenyo lokuhlola nokunciphisa ama-biopsies angadingekile.

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• Source: https://physicsworld.com/a/molecular-imaging-technique-could-improve-breast-cancer-screening/