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The Endocannabinoid System Explained – Why Cannabis Is Good for Our Bodies

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Cannabis has been pinned as a treatment option for many different disorders lately, many of them seeming completely unrelated. Everything from physical pain to mental disorders and even cancer are said to respond to cannabinoid treatments, but how exactly is that possible?

When you first start hearing about all the different conditions that medicinal cannabis is being used for these days, it almost seems like a gimmick to legalize. Can one plant, not to mention it’s a plant that gets you high, seriously have so many therapeutic benefits? Although it may seem like a stretch, if you have an understanding of the Endocannabinoid System, it makes a lot more sense why cannabis actually works so well in the human body.

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What is the Endocannabinoid System?

The only reason cannabis actually works and has an effect on us at all is because of the Endocannabinoid System (ECS). Simply put, the ECS is a network of receptors that exists in the bodies of all mammals, plus the endocannabinoids that bind to them. As a whole, the ECS regulates numerous different functions and processes in our bodies and maintains internal balance and homeostasis.

Researchers have discovered two different endocannabinoids so far, 2-arachidonoylglycerol (2-AG) and anandamide (AEA). 2-AG is made from omega-6 fatty acids and is present in fairly high levels in the central nervous system, but it has also been detected in human (and bovine) milk. 2-AG is a full agonist of both the CB1 and CB2 receptors, but it has a stronger influence over the CB2 receptor. Because of this, 2-AG is thought to have a substantial impact on the immune system.

Anandamide (AEA), also commonly referred to as the “bliss molecule”, is believed to play a major role in the in all of our basic daily physiological functions including sleep/wake cycles, appetite, mood, and even fertility; but we’ll get more in-depth on the benefits of this cannabinoid a bit later.

In addition to the naturally produced cannabinoids, there is also a large web of receptors that allow AEA and 2-AG to function the way they do. The two receptors that have been studied most extensively are CB1 and CB2. Cannabinoid receptors sit on the surface of cells and monitor conditions on the outside. Once they sense changing conditions and the body falling out of a state of homeostasis, they signal the appropriate cellular response to restore balance.

Anandamide: The Bliss Molecule

Although there are two known endocannabinoids, one is by far more prominent in research and literature: Anandamide (AEA). The reason AEA is known as the Bliss Molecule is because of the role in plays in balancing our body functions and elevating our moods. Multiple studies have been conducted on the benefits of being exposed to varying levels of anandamide.

Anandamide – The “Bliss” Molecule of the Endocannabinoid System

In 2015, a study examining both humans and rodents, found that high levels of anandamide contributed to mood elevation and fear reduction. When the enzymes that break down anandamide were inhibited, the subjects felt less fear and anxiety where threats were perceived.

2009 study linked anandamide to fertility by showing that high levels of this endocannabinoid were not only beneficial, but essential for regular ovulation and proper fetal development. The study also concluded that higher levels of anandamide during times of ovulation contributed to a healthy and successful pregnancy.

A slightly older study published in 2004 found that increased levels of anandamide the bloodstream created a “euphoric high” in people who had just performed rigorous exercise or physical activity. This is frequently described as a “runner’s high” or “adrenaline high”, and it’s likely the reason why people who use cannabis often feel that it contributes to their workout.

Although this is one of the more studied cannabinoids, there is still a lot that remains unknown about the bliss molecule the extent of its functions.

Clinical Endocannabinoid Deficiency

Clinical endocannabinoid deficiency is a recently discovered condition, some might call it a theory still, in which the body doesn’t produce enough endocannabinoids. As a result, the body becomes unbalanced leading to the onset of numerous different diseases and disorders.

According to acclaimed cannabinoid researcher Dr. Ethan Russo, people who are diagnosed with a clinical endocannabinoid deficiency can benefit tremendously by supplementing with phytocannabinoids – cannabinoids coming from plants.

Are You Suffering From Clinical Endocannabinoid Deficiency?

Migrainefibromyalgiairritable bowel syndrome and related conditions display common clinical, biochemical and pathophysiological patterns that suggests a clinical endocannabinoid deficiency that may be suitably treated with cannabinoid medicines,” Russo mentioned in his 2004 study. This research has been reviewed and echoed a couple times over the years, in 2014 and 2016.

The above conditions have the greatest evidence of being caused by a clinical endocannabinoid deficiency, however, there is an extensive and varied list of disorders that are likely related to this condition. These include neonatal failure to thrive, cystic fibrosis, causalgia, brachial plexopathy, phantom limb pain, infantile colic, glaucoma, dysmenorrhea, hyperemesis gravidarum, unexplained repetitive miscarriages, post-traumatic stress disorder, bipolar disease, and the list continues.

Neurological disorders have also been linked to a lack of natural endocannabinoids. Some experts believe that Alzheimer’s diseaseParkinson’s disease, and similar disorders can be treated with cannabinoids. This could be why people suffering from these conditions report success when self-medicating with cannabis products.

Final Thoughts

When you look at the whole picture, and realize how integrated cannabinoids are within almost every system in our bodies, it makes perfect sense why cannabinoid-based therapies are so successful at treating so many different conditions. The Endocannabinoid System has a role in all of our basic body functions, so if you’re feeling out of balance, can’t eat right, can’t sleep, suffering from anxiety, etc., the right blend of cannabinoids might be more effective than chemical pharmaceuticals at relieving your ailments and symptoms.

Thanks for stopping by CBDtesters.co, where we’re covering everything related to medical cannabis and legal cannabis business. Stop back frequently and subscribe to the Medical Cannabis Weekly Newsletter to keep yourself up-to-date.

The post The Endocannabinoid System Explained – Why Cannabis Is Good for Our Bodies appeared first on CBD Testers.

Source: https://cbdtesters.co/2020/06/16/the-endocannabinoid-system-explained-why-cannabis-is-good-for-our-bodies/

Blockchain

Bitcoin Lacks Transparency and Integrity, Says Trump Ex-advisor

Former Goldman Sachs president and COO Gary Cohn said that Bitcoin’s system has no owner or transparency—and that’s a flaw.

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In brief

  • Former Goldman Sachs president Gary Cohn said that Bitcoin’s system has no integrity because no one owns it.
  • “For all the reasons it’s a strong developing asset class, it may fail,” he said.
  • At the same time, Cohn praised central banks’ digital currencies as the evolution of money.

Gary Cohn, former president and COO of Goldman Sachs—who also served as Donald Trump’s chief economic advisor between 2017–2018—said that Bitcoin could fall just easily as it rose since its system has no transparency and integrity, according to Bloomberg.

“For all the reasons it’s a strong developing asset class, it may fail,” Cohn stated in an interview, noting that Bitcoin “lacks some of the basic integrity of a real market.”

Cohn voiced his criticism of Bitcoin just as the crypto experiences its second major price rally. It has recently broken its previous all-time high price—for the first time since late 2017—although has since dropped back down to $18,700.

However, Bitcoin’s main long-term problem is that it is not owned by any entity, according to Cohn.

Bitcoin and cryptocurrencies are here to stay. Image: Shutterstock

“Part of the integrity of a system is knowing who owns it and knowing who has it and knowing why it’s being transferred. The Bitcoin system today has no transparency to it. So there are a lot of people that question, why would you need a system that does not have an audit trail,” he added.

Notably, Cohn expressed much warmer sentiment towards digital money in April, when he stated that, “The slow rise of digital currency has been given a gigantic boost by the pandemic.” However, it now looks like he actually meant only cryptocurrencies created by central banks.

“If central banks around the world created digital currencies, each person could have a segregated account. This idea is gathering steam,” Cohn wrote in April, adding, “If that happened, all banking would happen through a digital backbone and wallet. ATMs and bank branches, which are already closing at a rapid rate, would become obsolete. Earnings would deposit directly into an individual’s wallet and be spent directly out of it.”

So, basically, the same as Bitcoin but without the “fatal flaw” of not being owned by banks? Right.

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Canaan Sees Over 75% Decline in Net Revenue in Q3 as Bitcoin’s Price Surge

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Chinese Bitcoin mining firm Canaan has recorded a loss in yet another quarter but is showing positive signs of a recovery as share price and market capitalization spikes. Following a disappointing initial public offering (IPO) last year and declining inventory sales, the company has seen the balance of power shift considerably to major competitors MicroBT and Bitmain.

$12.7 Million Loss for Q3 2020

Bitcoin miner maker Canaan has reported a 75.7% year-on-year (YOY) decline in net revenue as part of its Q3 2020 financials published on Nov. 30. In the report, Canaan revealed that its net revenue for the period was $24 million, which also amounts to an 8.5% reduction from the earnings recorded in the previous quarter.

Following the significant drop in quarter-on-quarter (QOQ) net revenue, it is unsurprising to see Canaan post another quarterly net loss in 2020. According to its Q3 2020 financials, the bitcoin mining chip maker recorded a net loss of $12.7 million, compared to a $2.5 million loss in Q2 2020 and $14.3 million in Q3 2019.

Commenting on the firm’s Q3 financial performance, Nangeng Zhang, Canaan’s CEO and Chairman said:

“During the third quarter of 2020, we remained undeterred by the pandemic to strengthen our research and development capabilities, expand our AI business, and execute new business initiatives. By leveraging our enhanced R&D capabilities in the third quarter, we launched our A1246 product series, which continues to lead the industry with its energy efficiency, computing power, and unit cost.”

Canaan Market Cap on the Rise

Net loss aside, Canaan has been recording some positives in the latter part of 2020. Indeed, the company’s market capitalization has more than tripled from $300 million in September to about $900.8 million as of press time.

Canaan’s share price has also been on a tear in recent months, rising over 200% within the same period. With one-third of Q4 remaining, the company’s stock has risen over 170%. Maintaining the current price action could see the Bitcoin miner manufacturer’s stock price challenge its IPO float price of $9, which incidentally is its all-time high share price.

Tweeting on Canaan’s Q3 performance, @WuBlockchain identified rising inventory sales and the release of the company’s A1246 miners are contributing factors to the firm’s recent resurgence.

Canaan was also among a group of Chinese mining hopefuls looking to float IPOs in the last couple of years. However, Canaan’s offerings fell short of the mark, failing to even realize a quarter of the $400 million estimate.

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Source: https://cryptopotato.com/canaan-sees-over-75-decline-in-net-revenue-in-q3-as-bitcoins-price-surge/

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Ethereum Prices Return to $620 Resistance on ETH 2.0 Launch Day

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Today marks the long-awaited genesis of Phase 0 in the Ethereum 2.0 upgrade roadmap which stretches ahead for the next couple of years. According to the Beacon Chain countdown, there is now less than seven hours to go before the genesis event spawns the first block on the new chain.

The Beacon Chain explorer reports that there is currently 872,000 ETH staked which equates to approximately $525,000 at today’s prices.

No Native Scaling For a Year

The excitement over the launch is palpable but many are still unaware that the new blockchain will not actually function as anything other than providing staking rewards to validators. All of the smart contracts, dApps, and transactions will continue as usual on the original ETH 1.0 chain.

Researchers at Messari Crypto pointed out;

“When the Beacon Chain launches tomorrow, outside of bootstrapping a network of proof of stake validators, it will have little functionality.”

This also means that there will still be issues with high gas prices when the existing network comes under heavy load which is bound to happen over the next year if DeFi momentum continues and the space evolves even more.

Phase 1 will introduce scaling through sharding, which will introduce 64 parallel side chains to take the load off the main chain and increase throughput. This is unlikely to occur for at least another year from today, and even then ETH 1.0 and 2.0 will operate independently until Phase 1.5 merges them together sometime in 2022.

Either way, the Ethereum community is hyped up over the event which is the culmination of five years of research and development for the world’s largest smart contract and decentralized application network. In his latest Bankless newsletter, David Hoffman aptly said;

“We were born too late to explore the globe, too early to explore the galaxy, but we were born at the perfect moment to explore the infinite whitespace of Ethereum 2.0.”

Ethereum Prices at Resistance

Ethereum prices have returned to their June 2018 price high of $620 just hours before the launch. This level appears to have formed a double top and heavy resistance zone as it did in early 2018. A next leg up could take prices to $800 where further resistance lies, but on the downside, support can be found at around $520.

At the time of press, ETH prices had retreated a little to trade at $605 but the momentum and potential is still with it.

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Source: https://cryptopotato.com/ethereum-prices-return-to-620-resistance-on-eth-2-0-launch-day/

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