Data published in the International Journal of Nanobiotechnology Peer-reviewed preclinical data in an anti-PD-1 resistant lung cancer model show that adding NBTXR3 to a combination of radiotherapy, anti-PD-1, and anti-CTLA-4 produced significant antitumor effects against both primary and secondary tumors, improved the mouse survival rate from 0 to 50%, and induced long term antitumor memory […]

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The post Axie Infinity (AXS) Price Manifest a Possibility of 30% Downswing as Buyers Fade Away appeared first on Coinpedia - Fintech & Cryptocurreny News Media| Crypto Guide

The NFT space is undergoing extreme price variations ever since the traders shifted their focus from the NFTs to the traditional cryptos. And since then the AXS price continues to showcase a weakened rally as it continues to maintain a notable downtrend. A significant 30% plunge is awaiting down the line and the strong support …

SINGAPORE, Jan 25, 2022 - (ACN Newswire) - 2021 was a huge year for the cryptocurrency market, with huge strides in growth and adoption of digital assets, NFTs, and blockchain worldwide. It was also an incredible year for Moonstake as we rose to the top rankings of global staking providers, reaching a total staking assets of $1.8 billion thanks to the support of our users and partners worldwide. As we begin the new year 2022, Moonstake as well as our strategic coin partners have many exciting news and programs in store for you as our platforms scale and evolve. To welcome our user community into the exciting new year, we're creating a series of articles in collaboration with our strategic partner on what you need to know about our partner coins in the year 2022, this time with Orbs.
As of April 2021, Moonstake has been supporting Orbs staking as an official network Guardian via strategic partnership with the Orbs Network development team. Since then, Moonstake has hosted a number of campaigns that promoted awareness and adoption of Orbs staking such as quizzes and giveaways. Currently, Moonstake is part of the upper echelon of all Orbs validators, ranking 10th amongst all 25 ORBS Guardians.

For Orbs, 2021 was a revolutionary year, a year of innovation, massive ecosystem growth and transformation. After solid research and strategic planning, the Orbs core team has decided to shift much of its focus to the DeFi and NFT space, as Orbs team believes that DeFi and NFTs are already emerging as the best use cases of blockchain technology.

Orbs also welcomed a number of new Guardians, including Moonstake of course and Japanese guardian, D-Kuru to its network to enhance security and performance. It also made key integrations with leading DeFi-focused blockchains including Solana, Binance Smart Chain, Polygon, Harmony, and Avalanche to accelerate its DeFi drive and strengthen its position as a multi-chain asset.

In this article, we will be interviewing our partner at Orbs about what is in store for the Orbs ecosystem and its user community in 2022.

Q1 Which 2021 achievements are you the most proud of?

Since making the shift to DeFi, Orbs has seen a rapid expansion of its ecosystem. Let's list here some of the prominent innovations and integrations Orbs team has recently announced:

- Orbs is now live on all 6 major layer-1 (L1) chains: Ethereum, BSC, Polygon, Solana, Avalanche and Harmony. This in turn accelerated the integration of the Orbs ecosystem with over 17 major DeFi protocols (such as UniSwap, SushiSwap, PancakeSwap, Kyber Networks, 1inch, Alpaca Finance, Beefy Finance, QuickSwap, DinoSwap, Raydium, Trader Joe, Pangolin and more.

All of these multi-chain integrations set down the necessary foundation for Orbs' further expansion. Orbs' DeFi interoperability plays a critical role for the next stage of the project's roadmap, as a layer three (L3) independent execution layer.

At this stage, the project is focused on utilizing the Orbs Network as a separate execution layer that operates in conjunction with EVM-based L1s and L2s chains to enhance the capabilities of EVM smart contracts. We like to call this architecture - L3 execution layer.

- The Orbs public blockchain infrastructure, powered by its Guardians, a public network of permissionless validators, now enables a separate L3 execution layer that operates in conjunction with EVM-based L1s and L2s, all powered by the ORBS token PoS.

Orbs' L-3 capabilities are deployed in Open DeFi Notifications Protocol - an open initiative to provide DeFi users with decentralized and free mobile notifications for on-chain events. This is the first project by the team that will utilize and demonstrate Orbs' unique L3 positioning as a layer 3 execution protocol. Right from the launch we already have a top-notch roster of leading DeFi protocols having their platform integrated into the Notification App. These protocols are across multiple chains such as Ethereum, BSC, Polygon and Avalanche, and multiple functionalities: DEX-AMMs, yield aggregators and vaults.

The availability of functioning L2 chains together with Orbs' rapid expansion into multiple chains, paved the way for various exciting and innovative applications for the Orbs network that were not available before. These include Orbs as a Layer 3 infrastructure for DeFi applications.

- These integrations also allow for the Orbs Network to diversify and add another blockchain to its hybrid architecture by implementing multi-chain staking. Instead of having the Orbs Token staking just on Ethereum, Delegators will have the option of being part of a parallel staking system on Polygon.

Orbs has recently become one of the first players to introduce multi-chain staking on Ethereum and Polygon; this strategic solution is even expected to completely mitigate the current high Ethereum gas costs for Orbs delegators interacting with the Orbs staking contracts.

For more information - you are welcome to check out our social media channels, news and blog pages to see that the project's scope is rich and diverse.

Q2 What measures are you going to take in 2022 to further increase adoption of Orbs?

As was stated above, the team is currently working on further developments of the L3 architecture and multi-chain Orbs PoS staking, having started with the Polygon network.

The Orbs team is currently working on the technical details of the multi-chain Orbs PoS staking proposal. In parallel, the project will initiate ongoing discussions with the Orbs Guardians and the Orbs community to present and review the various aspects of this proposal for notes and feedback.

The Orbs team is extremely excited about this initiative which addresses one of the key feedbacks from the community following the V2 launch. Staking on Polygon will boost inclusion and participation of Orbs token holders in the PoS Universe staking, as well as solidify Orbs as a multi-chain protocol.

Q3 What can users expect from Orbs in 2022?

In 2022, Orbs will implement an architecture where a major part of its governance mechanism is deployed on multiple chains.

Staking on Polygon is expected to boost inclusion and participation of Orbs token holders in the PoS Universe staking, as well as solidify Orbs as a multi-chain protocol.

As can be seen, Orbs team is always researching new opportunities for the project to explore, new chains to expand, new strategic integrations to consider, and new technical features to test.

We suspect few people can truly foresee how crypto space will further evolve even in the next year; with this being said, Orbs is planning to keep strengthening its position in the DeFi and NFTs spaces, further exploring the diverse opportunities these sectors may unfold.

Moonstake is proud to be strategic partners of Orbs. We will continue to maintain strong support for the ever growing and developing Orbs ecosystem and hope to bring even more great value to ORBS and crypto users worldwide in 2022 to help accelerate adoption of the Orbs and Moonstake ecosystems together.

About Moonstake

As a world-leading staking service provider, Moonstake develops and operates decentralized wallet services for enterprises and end users.

Our full-scale staking business started in August 2020. With the support of users all over the world, our total staking assets has risen to 1.8 billion dollars. In June 2021, we ranked third among 15,000 staking providers globally.

So far, we have expanded our business and ecosystem through about 30 strategic partnerships, including major blockchains such as Emurgo which is a constituent organization of Cardano, TRON, and NEO. In May 2021, we became a wholly owned subsidiary of the listed company "OIO Holdings Limited" on the Singapore Stock Exchange and we are working to further expand Moonstake's business and improve our credibility. https://www.moonstake.io/

About Orbs

Orbs is a public blockchain infrastructure designed for mass usage applications. The Orbs protocol is decentralized and executed by a public network of permissionless validators using Proof-of-Stake (PoS) consensus.

Orbs unique features designed for interoperability with EVM-compatible blockchains, together with its decentralized network of nodes, allow it to be set up as a separate execution layer ("L3") operating to enhance the capabilities of EVM smart contracts. By working in conjunction with other L1 and L2 solutions as part of a tiered blockchain stack, Orbs opens up a whole new spectrum of possibilities for DeFi, NFT, Metaverse and GameFi.

Orbs was founded in 2017 and launched its mainnet and token in March of 2019. Orbs is being developed by a dedicated team of more than 30 people, with offices in Tel Aviv, London, Singapore, Tokyo and Seoul. For more information, please visit www.orbs.com, or join our community at:
- Telegram: https://t.me/OrbsNetwork
- Twitter: https://twitter.com/orbs_network

Copyright 2022 ACN Newswire. All rights reserved. www.acnnewswire.comAs we begin the new year 2022, Moonstake as well as our strategic coin partners have many exciting news and programs in store for you as our platforms scale and evolve. To welcome our user community into the exciting new year, we're creating a series of articles in collaboration with our strategic partner on what you need to know about our partner coins in the year 2022, this time with Orbs.

Myanmar's military council is pushing to ban crypto one month after the country's exiled government floated Tether as official tender.

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The crypto town is now in turmoil over the plan of action, while the business remains in a quagmire. The recent market crash and the uncertainty of the near future have left merchants wondering about their trade practices. Whilst novices and smaller players have changed hands with the whales, older hands are considering buying assets …

Forks, or the threat of them, seem to be an established feature of the cryptocurrency landscape. But what are they? Why are they such a big deal? And what is the difference between a hard fork and a soft fork? A “fork,” in programming terms, is an open-source code modification. Usually, the forked code is…

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There’s a silver lining in everything and the COVID19 pandemic has certainly filled many coffers with both gold and silver. One of the industries riding on this freak wave is the video game one, whose value is projected to reach no less than US$175,060m in 2022, all at an impressive annual growth rate of 8.17%. …

Today, as machine learning techniques are widely applied to a range of applications, machine learning has become important to online services. Morphware is a decentralized machine learning system that rewards owners of accelerators by auctioning off their idle computing power and then facilitates the associated sub-routines, which can be on behalf of the data scientists [...]

The post Morphware: Making Machine Learning Work for Blockchain appeared first on Blockonomi.

Cardano (ADA) is a third-generation blockchain. What does that mean? In a nutshell, it builds on all the lessons learned from other coins to create a layered and distributed computing platform that places a special emphasis on security and engineering rigour. Cardano was officially launched in September 2017 under the so-called ‘Byron’ bootstrap phase. It […]

The post Cardano Deep Dive: Info you NEED about Cardano and ADA appeared first on Coin Bureau.

The price of Cardano (ADA) surged and plunged on the same day, starting with the excitement around the launch of its first decentralized exchange, the DEX SundaeSwap, then following the downtrend of Bitcoin. SundaeSwap’s Wins And Failures ADA’s price had been up around 10% in the last week tied to the launch of Cardano’s beta…

The post Cardano Price Up And Down Amidst SundaeSwap Launch appeared first on Bitcoin News Miner.

Cardano is one of the most widely used types of cryptocurrency, a type of digital currency that can only be used online. Cardano was founded in 2015 and first traded publicly in October 2017 for a few pennies per token. The currency is now worth more than $1.20 in January 2022, after having peaked at more than $3 in the previous 52 weeks. It is one of the top ten most valuable cryptocurrencies in total value. Cardano was established by Charles Hoskinson, a co-founder of Ethereum, another renowned cryptocurrency, and it uses blockchain technology to run on a decentralized public ledger. Like an unending receipt, Blockchain administers and monitors the cryptocurrency, documenting, and arranging every transaction that occurs with it. This decentralized mechanism validates transactions, checks their integrity, and aids in the system’s overall stability and error-free operation. In addition, Cardano has a “proof-of-stake” method, in which currency owners are entrusted with verifying transactions in exchange for a reward. This “staking” incentive might be a fun way to get money. What Is the Origin of Third Generation Crypto Cardano Coins? According to CoinMarketCap, there were approximately 33.5 billion ADA in circulation as of January 2022. Therefore, the entire supply of coins is limited to 45 billion. Cardano is similar to Bitcoin in that it has a fixed quantity of 21 million units. And it’s in contrast to Ethereum, which has an endless supply but a limited annual issuance. The proof of stake approach in Cardano lets those who hold the cryptocurrency have an interest in the system’s integrity – validate transactions on the Blockchain. Then, these validators get compensated (in a crypto coin). Stakers, on the other hand, may lose money if validators approve invalid transactions. You can stake your coins with a validator and receive commensurate compensation as a cryptocurrency owner. However, there is usually a cost for this service. What Is the Function of the Cardano Cardano’s platform supports several different features: Cardano is a cryptocurrency that may be sent and received, as well as transferred in exchange for products and services, using a cryptocurrency wallet. Cardano supports smart contracts, which autonomously self-execute when the contract’s criteria are met. Cardano enables people to interact directly and without authorization with other persons or companies, bypassing middlemen such as banks and other financial institutions. Cardano can enable lending, trading, asset management, insurance, and other common financial activities decentralized finance. Cardano RoadMap The Cardano roadmap is a timeline of the cryptocurrency’s evolution, divided into five eras: Byron, Shelley, Goguen, Basho, and Voltaire. Each era is defined by features that will be delivered over several code releases. While the Cardano eras will be delivered in order, the work for each era is done in parallel, with research, prototyping, and development happening simultaneously across the many development streams. Each era’s work is collected and exhibited on its page, signifying years of effort. Here you’ll find a summary of the era’s goals, as well as descriptions of the key functional components, connections to related academic research, status updates, and even real-time code changes. Phases of Cardano Development Cardano is being developed in five stages to be decentralized applications (DApps) development platform with a multi-asset ledger and verified smart contracts. Each of the five phases is referred to as an era and is named after a significant historical figure. The five eras, or phases, are as follows: Foundation (Byron era) Cardano is a third-generation blockchain built from the ground up with research, peer review, and a strict formal development strategy in mind. The tale began in 2015 to address the three major strategic difficulties that all blockchain networks face: scalability, interoperability, and long-term viability. Finally, after two years, thousands of GitHub commits, and hundreds of hours of research, Cardano’s first version was released in September 2017, ushering in the Byron era. Decentralization (Shelley era) Following the Byron era, Cardano’s Shelley era is a period of expansion and development for the network. However, unlike the Byron era, which began when the mainnet was established, the transfer to Shelley is intended to be a seamless, low-risk shift with no service interruptions. The Shelley period covers Cardano’s crucial early moves toward decentralization — which, like any initial step, will be modest but substantial. Smart Contracts (Goguen era) With the addition of smart contracts, the Goguen period marks a significant advancement in Cardano’s capabilities. Whereas the Shelley period decentralizes the system’s core, Goguen builds on Cardano’s robust foundation of peer-reviewed research and high-assurance development to allow users to create decentralized applications (DApps). Scaling (Basho era) The Cardano Basho period is one of optimization, with the network’s scalability and interoperability being improved. Whereas past development eras focused on decentralization and new functionality, Basho is all about enhancing the Cardano network’s actual performance to facilitate growth and acceptance for high-volume applications. … Continued

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Swiss traditions of security, neutrality and privacy have made the country a magnet for digital asset holders, Numbrs CEO Fynn Kreuz told Decrypt.