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Oculis Strengthens Leading Ophthalmology Pipeline by In-Licensing Neuroprotective Drug Candidate for Glaucoma from Accure Therapeutics
ACT-01, which is being renamed OCS-05, is a first-in-class small molecule with neuroprotective activity that has shown positive results in animal models of neuroinflammation and neurodegeneration. Its mechanism of action is related to the activation of the trophic factor pathways such as IGF-1 and BDNF. In ophthalmology, this action can protect the nerve axons in conditions where the optic nerve is affected, such as in acute optic neuritis and glaucoma, where the OCS-05 could prevent chronic vision loss.
Based on positive preclinical data and results of a phase 1 safety and PK study in healthy volunteers, a phase 2a study was initiated (the ACUITY study).
ACUITY is a two-arm, randomized, double-blind, placebo-controlled, monocentric study to evaluate the safety and tolerability of OCS-05 compared to placebo in patients with acute optic neuritis. In addition to safety, secondary outcome measures will include optic nerve anatomical measures, as well as visual function measures. The study is ongoing at the La Pitie-Salpetriere hospital in Paris within the neurology-ophthalmology network of the Public University Hospital Group in Paris (APHP). One third of the planned sample size has been enrolled.
Oculis is currently planning the expansion of the program in ophthalmology working with the regulatory agencies in the US, EU and China amongst others.
Riad Sherif, M.D., CEO of Oculis, said: "We are excited about this agreement as it combines Oculis's ophthalmology expertise with Accure's unique neuroprotective approach to help transform the treatment of neurodegenerative diseases in ophthalmology. At Oculis, our focus is on building a highly innovative and differentiated pipeline providing life changing treatments for ocular unmet medical needs, and OCS-05 is a perfect fit for that ambition. Glaucoma is a leading global cause of irreversible blindness, and despite IOP lowering treatments, a significant proportion of patients still go blind. With OCS-05, we have the potential to bring to market the first neuroprotective for glaucoma and other optic neuropathies."
Laurent Nguyen, M.D., Co-founder and Chief Executive Officer at Accure Therapeutics, said: "Having shown promising early data and potential in a number of ocular disease indications, the timing is right for a partnership between two like-minded companies committed to patients and driven by a passion for neuroscience. By leveraging its expertise in ophthalmology, Oculis has the potential to fulfill the promise of this exciting asset in a wide range of neurodegenerative diseases."
In reference experimental animal models of acute optic neuritis (acute inflammatory demyelinating disorder of the optic nerve) and high-pressure glaucoma (high eye pressure damaging the optic nerve and leading to permanent vision loss), OCS-05 reduces damage to the optic nerve and retina. It also decreases paralysis progression in an autoimmune encephalomyelitis animal model for multiple sclerosis (inflammation caused by the body's immune system, which destroys nerve cell processes and myelin in the brain and spinal cord).
Data from a completed phase 1 study show the safety and tolerability of single and multiple doses of OCS-05 in healthy volunteers.
Under the terms of the agreement, Accure Therapeutics will receive an upfront payment, potential milestone payments upon the achievement of certain development and commercial milestones, and tiered royalties on sales.
Anthony Rosenberg, Chairman of Oculis's Board of Directors, said: "The addition of OCS-05 to Oculis's pipeline is very much in line with the Company's strategy to develop transformative therapies that address the root cause of ocular disease to improve patients' sight and quality of life. There is a clear need for first-in-class therapies that can protect and prevent damage to the optic nerve and retina. Oculis has the team and expertise to bring OCS-05 through clinical trials and ultimately to patients around the world."
Montserrat Vendrell, Chairman of Accure Therapeutics and Partner at Alta Life Sciences added: "This licensing deal with Oculis is a proof-of-concept of the value creation that Accure Therapeutics brings as a translational R&D engine, taking forward truly unique science that spun-off from the University of Barcelona. This licensing agreement will enhance Accure's capabilities to accelerate and expand value potential for the rest of its pipeline."
About Oculis
Oculis is a global biopharmaceutical company purposefully driven to save sight, improve eye care and address significant unmet medical needs with breakthrough innovations. Oculis's highly differentiated pipeline includes candidates for topical retinal treatments, topical biologics and disease modifying treatments. With a presence in key international markets, Oculis is poised to deliver life-changing treatments to patients worldwide.
Headquartered in Lausanne, Switzerland and with operations in Europe, the U.S. and China, Oculis is led by an experienced management team with a successful track record and supported by leading international healthcare investors.
For more information, please visit: www.oculis.com
About Accure Therapeutics
Accure Therapeutics is a private translational neuroscience R&D company. Based in Barcelona (Spain), it was launched in 2020 with a Series A funding led by Alta Life Sciences Spain I and supported by the Centre for Technological and Industrial Development (CDTI). This European company with an international mindset boasts a unique portfolio of three new chemical entity programs pursuing innovative targets - with potential to accommodate others. Accure aims to develop new disease modifying drugs to treat serious conditions such as optic neuritis, multiple sclerosis, Parkinson's disease and epilepsy. With an experienced business and scientific team, Accure Therapeutics is one of the few companies that operate in an agnostic fashion on initial science to deliver cutting-edge drugs in CNS.
To learn more visit https://accure.health/
Copyright 2022 JCN Newswire. All rights reserved. www.jcnnewswire.comOculis S.A., (Oculis) a global ophthalmology company developing life-changing treatments to save sight and improve eye care with breakthrough innovations, and Accure Therapeutics, a private translational neuroscience R&D company
MHI Joins “ACT FOR SKY,” a voluntary organization working for the Commercialization, Promotion and Expansion of Domestically Produced SAF
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"ACT FOR SKY" with "ACT" representing the cooperation and collaboration by companies committed to take "action" for these goals-will aim to raise awareness among citizens and companies of the importance of SAF, carbon neutrality and achieving a circular economy. Applying expertise across relevant industries, the four founding companies will coordinate the activity of other member companies as well.
MHI is embarking on a project to develop a commercial-scale supply chain for sustainable aviation fuel (SAF) derived by biomass gasification integrated with FT synthesis technology(2). By achieving reduction in greenhouse gas emissions caused by jet fuels, the Company will contribute to mitigating the aviation industry's impact on the global environment.
Background
- A rapidly growing global need to reduce CO2 emissions has called for the aviation industry to accelerate the development, production, distribution, and use of SAF. This fuel is sourced from sustainable resources such as tallow (animal oils and fats), used cooking oil (UCO), biomass, municipal solid waste, exhaust gases, and CO2.
- As global SAF demand grows, a stable supply of domestically produced SAF is considered essential in Japan. However, domestically produced SAF has not been commercialized yet, and establishing stable supply chain, from procurement of feedstock to supply of SAF, remains an urgent issue.
- Compared to Europe and the U.S, where SAF is already being commercialized, and its awareness is relatively strong, it is necessary to raise the awareness of SAF in Japan as well.
Overview of activities
- Promotion of the members' activities toward decarbonization and a circular economy through the domestic production of SAF
- Discussions and analysis on the costs to achieve these goals
- Raise awareness on carbon neutrality, through local governments and education
- Exchanging information among members, for next actions
- Share information on how other countries are acting for SAF promotion
- Identify common issues for domestic SAF production, and share the information and analysis gathered with related organizations
Specific member initiatives
ACT FOR SKY consists of the following 16 members (as of March 2, 2022).
"ACT" member companies: Companies/organizations directly involved in domestic SAF business
(founding companies in bold)
Future development
Along with a variety of other stakeholders, ACT FOR SKY will promote and expand the domestic production of SAF, which will lead to the development of aviation network in Japan and the industry related to SAF production. Together, we will establish a sustainable society.
ACT FOR SKY logo
Created by: Housui Yamaguchi, calligrapher
Behind the logo design:
Blue ink: A beautiful blue sky
Calligraphic style: Dynamic, linked to action
Symbolism of calligraphy: Japan, domestic production
(1) SAF is a fuel achieving significantly lower CO2 emissions compared to the conventional jet fuel over its life cycle, from production or collection of feedstock (such as biomass, used cooking oil, or exhaust gas) to manufacturing and combustion. Existing infrastructure can be used without modification.
(2) Gasification and FT (Fischer-Tropsch) synthesis technology: a technology whereby solid materials such as wood cellulose are reacted with water vapor and a small amount of oxygen in a gasifier to produce carbon monoxide and hydrogen (gasification), which are then synthesized into liquid hydrocarbons (fuel) in an FT reactor using a catalyst (Fischer-Tropsch Process).
About MHI Group
Mitsubishi Heavy Industries (MHI) Group is one of the world's leading industrial groups, spanning energy, logistics & infrastructure, industrial machinery, aerospace and defense. MHI Group combines cutting-edge technology with deep experience to deliver innovative, integrated solutions that help to realize a carbon neutral world, improve the quality of life and ensure a safer world. For more information, please visit www.mhi.com or follow our insights and stories on spectra.mhi.com.
Copyright 2022 JCN Newswire. All rights reserved. www.jcnnewswire.comMitsubishi Heavy Industries, Ltd. (MHI) is pleased to announce that today it has joined "ACT FOR SKY," a voluntary organization established jointly by JGC Holdings Corporation Co.,Ltd., REVO International Inc.
Metaverse Opening Doors For Artists
Our globe has seen countless historical shifts and transformations in technology domains in the past, all of which have aided in the development and advancement of human existence. In the same vein, the term ‘Metaverse‘ has now been added to the list as the most recent technological advancement. The Metaverse is a notion for a virtual world that will be available in virtual reality (VR). People will be able to connect, communicate, and build their businesses in a whole new way in the metaverse, thanks to the newest virtual reality and augmented reality technologies. Working from home would become more advanced. People who work online from anywhere in the world could potentially meet up with their coworkers in the metaverse in their virtual form. And this technology has only started to spread its branches. While the concept of the metaverse as a virtual mirror of the real world may appear exaggerated and largely fictitious, several key players have begun to experiment with the use of virtual spaces for the visual arts, pushing the boundaries of how digital and physical art can be discovered, viewed, shared, and experienced to new heights. Metaverse and the Art World The metaverse is increasingly extending its linkages with the traditional world of high-end art, NFTs, and the metaverse. Sotheby’s (the Fine Arts Company) Metaverse, the auction house’s new platform developed particularly for digital collectors and including NFTs curated by art experts, was just launched. Following partnerships with crypto artists and collectors, this is Sotheby’s newest foray into the digital art world. The issue around non-fungible token art was thrust from relative obscurity into the spotlight after digital artist Beeple sold his everyday piece for $69.3 million in March 2021. The boom has benefited artists all around the world, allowing them to get access to lucrative new prospects through a worldwide audience while avoiding the conventional gatekeepers of the commercial art industry and instead of forming direct relationships with their collectors. Artists now have extraordinary digital property rights thanks to the ability to mint their creations as NFTs, with blockchain-enabled smart contracts allowing them to collect a pre-programmed and automatic royalty on any future sales of their work via secondary marketplaces. Since 2008, digital work has been around and grabbing attention, and the metaverse has just added another exponential layer on top of that. Several individuals are being hired here to work on constructing metaverse games, which reminds me of the early days of the internet when people were jumping at the chance to work on dot-com ventures. And that’s only one component; folks are also finding success by remaining independent and developing their own NFT initiative. What is Meta’s Vision For Virtual Art? The company formerly known as Facebook has recently been subjected to a great deal of scrutiny. Unfortunately for Zuckerberg and his colleagues, their virtual art concept is doomed from the start. Many critics argue that the company’s vision of the future of digital art is too narrow and simplistic, despite the company’s recent release of a film encouraging viewers to ‘enter a realm of creativity with Meta and explore endless possibilities in 3D.’ Even the biggest skeptics, as ArtReview’s Orit Gat put it, can’t help but be attracted by the themes in Meta’s video. He said: “A young woman walks through a museum and stops by a Henri Rousseau painting, Fight between a Tiger and a Buffalo (1909), only to get sucked into the painting and see it turn into something closer to Where the Wild Things Are: an animated tiger asserts ‘This is the dimension of imagination,’ while toucans and flamingos bob away to the beat.” The Door of Opportunities For Artists The computerized world provides artists with their laboratories to investigate various aspects of online personas and genuine identities. Even actual works of art have made their way into the digital sphere. Many artists used the Nintendo Switch’s Animal Crossing: New Horizons to turn their virtual homes into makeshift galleries during the early months of the pandemic, using a gaming function to digitize photographs of their artworks into pixelated images that could be arranged to look like canvases on the walls.
The post Metaverse Opening Doors For Artists appeared first on Cryptoknowmics-Crypto News and Media Platform.
SincereDoge Acquires a KYC/ Smart Contract Audit Report Through SolidProof
The process was successfully handled by SolidProof, which operates as a blockchain security firm.
Boosting Investors' Confidence
Sincere Doge conducted the first stage of running a KYC verification process on January 25, 2022. SolidProof then proceeded with another version of KYC verification on February 1, 2022. Through both processes, the project hopes to curb security concerns, a growing menace in the crypto world.
The process also provided developers with various recommendations to improve the code's operations. Smart contracts usually apply complex codes that only individuals with technological experiences can handle.
By continuously performing tests on the code, the security experts and project developers identify errors that may compromise investors. Furthermore, the process makes it easier for regular users who don't have technical skills to carry out an audit.
On the other hand, SolidProof's KYC solution will safeguard Sincere Doge from financial crimes such as fraud and money laundering. The solution accomplishes these goals by examining money laundering threats or verifying an investor's identity.
SincereDoge Presale is Coming Soon
SincereDoge will host a presale event in February 2022 and attain a hard cap of 300BNB. The platform's native asset ($Sdoge) is already live on CoinMarketCap and CoinGecko. Listing prices go for 183T Sdoge tokens, equivalent to 1 BNB. Investors can acquire more than 203T Sdoge from the presale price rate using 1BNB.
Investors are limited to spending a minimum of 0.8BNB during the fundraiser. Sincere Doge targets to allocate 60% of its tokens to the presale and dedicate the remaining 40% into liquidity.
Transaction charges are also applicable on every buy/sell trade. Thus, investors attract an 8% transaction fee whereby 3% of the charges go to NFT development initiatives. The remaining 3% and 2% will cover marketing activities and rewarding $Sdoge holders.
Future Developments
In Q4 2021, the project managed to accomplish various goals during its inception. Among the activities that Sincere Doge concluded include social media marketing and its white paper/website launch.
Moving forward, the project targets to obtain more than 100,000 holders within 2022. It may further feature other crypto trading platforms such as PancakeSwap, Coinsbit, and Coinbase. An additional exchange known as the SincereDogeSwap is also set to launch in the future.
To engage the community, Sdoge hopes to form charity teams and participate in several donation events. Such charity initiatives help rescue dogs in need and create a stronger bond with the public. The donations will then fund the construction of an animal sanctuary.
About Sincere Doge
Sincere Doge is an innovative ecosystem that intends to launch a meme coin with advanced transaction speeds. Investors gain holder rewards from every transaction that takes place in the project. More importantly, Sincere Doge guarantees security and transparency to its investors using SolidProof's security measures.
You can read more about Sincere Doge and follow up on new developments from their pages:
Website: https://www.sinceredoge.com/
Twitter: https://twitter.com/sincere_doge
Telegram: https://t.me/SincereDoge_Global
SafariSwap Launches Limited Edition of Chinese New Year Special NFT Collection, $NatureToken Now Listed on CoinMarketCap and Coingecko
SafariSwap is a new network known for being the fastest and the safest platform for liquidity pooling and its dex based operations.
Recently, Safariswap has announced a new non-fungible token (NFT) for the Chinese Year of the Tiger, it launched exclusive pieces of 888 collectables on February 7. Ahead of the launch of these NFTs, the $NATURE token now has been listed on leading well-known exchanges Coinmarketcap and Coingecko.
What is Safariswap?
SafariSwap is a community-based and driven automated market maker (AMM), which aims to build an animal-friendly and animal lovers-based community which will not only work towards a sustainable living environment for animals but also revolutionize wildlife conservation plans and undertakings around the globe.
Safariswap also has its safari themed NFTs and holders of Safariswap NFTs are well-cited with mystery gifts and promising price preference. Besides, its highly optimized and user-friendly gaming system delivers high yield and huge APY if the holders are contributing to the NFT staking program and also for the users who are holding the $NATURE token which is the native token of Safariswap.
SafariSwap $NatureToken- distribution and working
The SafariSwap token, $Nature, is a high yield staking LP token that provides rewards to its community via liquidity mining and NFT gamification.
The token not only advantages token holders who HODL but also those who participate in the SafariSwap NFT ecosystem, enabling them to swap their tokens for fresh NFTs or upgrade up their prevailing NFTs to receive more rewards and huge APY. This system in turn impetuses token price evolution. SafariSwap's massive rewards model can be an integral part of the strategy for individuals who are looking to invest and earn sedentary income.
By staking safari swap NFTs in the ecosystem, it enables the users to passively earn enormous proportions of rewards which are instantly and automatically distributed to holders allowing effective and seamless experience in migrating assets from other similar liquidity pools.
SafariSwap's $NatureToken Listed on CoinMarketCap and Coingecko
The $Nature token now has been officially listed on coinmarketcap and coingecko allowing users to gather live, up to the minute market research, trading data, and token performance. Coinmarketcap and coingecko are some of the world's largest exchanges for buying, selling, and trading cryptocurrencies. CoinMarketCap is one of the most referred crypto price tracking websites. Coingecko being one the earliest and largest data aggregators in the industry, Safariswap is proud to announce that it is now a part of the 4,700 coins and over 300 exchanges community.
Previously, the token has also been listed on DEX like pancakeswap. The listing has boosted the liquidity of SafariSwap and the price of $NatureToken higher by 20%, two days after the announcement. NatureToken also registered about 4.0% growth on coingecko.
This is the right time for users to invest in buying the $NatureToken directly from CoinMarketCap to assure them of earning profit in the future. Users will also get the chance of earning big staking rewards, huge APY, and increasing their profit by 10 times. It's your chance to act as a smart investor and make sensible future investments by investing in the $NatureToken.
Availability of The NatureToken on Coingecko will also help the users to access the crypto data of the token.
On Coingecko users cannot buy or sell the token directly however, investors can gather better awareness of NatureToken by accessing transparent and qualitative facts and achieving insights such as trust score, 24-hour reported trading volume, market capitalization, circulating supply etc.
SafariSwap offers special NFTs for Chinese New Year
Safariswap is marking the Chinese lunar new year with the launch of a limited set of 888 pieces of collectables. Launched on February 8th, The price structure of these collectables is fixed as 100 USD and they can be purchased directly from the SafariSwap dapp.
To wish all users good luck, health and longevity for the Lunar New Year, SafariSwap has launched these collectables, "As a way to give back to our community for its continuous support". Don't miss this unique and exclusive NFT collection and gather the most rare and exclusive NFTs.
Why get Safariswap New Year NFTs?
SafariSwap strives to nurture the multitudes on the significance of wildlife and habitat conservation, By putting an end to practices like poaching and hunting of endangered species. Thus evolving the creation of revenue opportunities for the neediest communities in the world that are implicated in habitat contortion.
Besides doing good by donating a fraction of the revenue to wildlife organizations, all NFTs that are launched inclusive of the New Year NFT will be part of the roadmap where users will stand to receive a special lump bonus and join in special events only if users own a piece of this limited NFT.
The proceeds have been divided into the following models:
50% of the proceeds will go to Jackpot.
30% of the proceeds will go to company development.
20% of the proceeds will be donated to a selected wildlife conservative organization.
Therefore, Safariswap invites you to begin this journey of investment that helps in taking a step forward to put an end to the illegal trafficking and killing of endangered wildlife animals.
How to purchase these Safariswap's special NFTs?
The below steps will guide you on how to purchase these limited New year's themed NFTs.
1. Prepare 100 USDT in your Dapp wallet
2. Access via your wallet browser: https://app.safariswap.io
3. Connect your wallet & click on the "Buy NFT" function
4. Click the "Approve" on the Lunar New Year NFT
5. Buy the Lunar NFT using the 100 USDT
6. You may check the NFT under "My Collection" after it is purchased
Safari swap is not just a mode for income production, it's a representation of a sustainable planet. It's your chance to invest in the betterment of the world.
Coinmarketcap: https://coinmarketcap.com/currencies/the-nature-token/markets/
Coingecko: https://www.coingecko.com/en/coins/the-nature-token
Safariswap: https://www.safariswap.io/Raghav Sawhney
Outreach Manager SafariSwap
[email protected]
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